A mitochondria-derived peptide researched for metabolic regulation and exercise-related stress responses. Still early relative to incretin drugs, but frequently searched in biohacking circles.
Metabolic · Fat loss · Recovery · Longevity / aging
A 28-amino-acid immunomodulatory peptide, marketed in dozens of countries as Zadaxin/thymalfasin for chronic viral hepatitis and as an immune-response adjunct in cancer and infection. One of the few peptides in this space with genuine international drug-approval history.
Immune support · Longevity / aging
A 24-amino-acid peptide encoded within mitochondrial DNA itself, part of a growing family of "mitochondrial-derived peptides" (alongside MOTS-c) studied in aging and cellular-stress biology.
Longevity / aging
A synthetic tetrapeptide associated with pineal peptide research and aging biology conversations. Evidence is largely historical/preclinical with limited modern RCT coverage.
Longevity / aging · Sleep / recovery adjunct · Recovery
A lab-designed "D-retro-inverso" peptide built to disrupt one specific protein-protein interaction that keeps aged cells alive, making it a purpose-built senolytic rather than a naturally occurring hormone fragment. Widely cited in longevity media as the "reverse aging in mice" peptide.
Longevity / aging
Evidence labels
- EmergingMostly preclinical or early signals; human athletic data is thin.
- Limited human dataSome human pharmacology or small studies; outcomes for fitness use remain limited.
- Stronger clinical signalSupported by larger clinical trials in defined medical populations.
Same color code everywhere on STACKD: green = stronger clinical/human data, amber = limited human data or mechanism, slate = emerging/anecdotal, and oxblood = an in-house STACKD summary.